Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits

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dc.contributor.authorMuhammad Asif1, Ayesha Safdar Chaudhry, Ambreen Ashar, Hamad Bin Rashid, Muhammad Hassan Saleem, Hassaan Bin Aslam, Abdul Aziz
dc.date.accessioned2024-07-18T14:25:59Z
dc.date.available2024-07-18T14:25:59Z
dc.date.issued2023-05-09
dc.descriptionKing Ceasor University, College of Medicine & Life Sciences, Uganda.
dc.description.abstractThe study was about Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits. The main objective was to synthesize zinc oxide nanoparticles (ZnONPs) and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). The methods used were as follows: ZnONPs were prepared using the sol-gel method and characterized by X-ray diffraction (XRD) analysis and scanning electron microscopy (SEM). Eighteen rabbits were divided into three groups: the ZnONPs group, the gentamicin group, and the control group. Each rabbit was inflicted with a 3 cm^2 wound contaminated with MRSA inoculum. Treatment commenced on the fourth day post-surgery. Wound healing, microbiological analysis, and histopathological analysis were performed to assess the efficacy of ZnONPs ointment. The results are: XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 nm. SEM revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 nm. Energy-dispersive X-ray analysis confirmed the purity of ZnONPs. Moreover, the particle size ranged from 100-700 nm with a high agglomeration trend. Treatment with ZnONPs promoted the healing of MRSA-infected wounds. Additionally, ZnONPs exhibited a good antibacterial effect, as evidenced by a dose-dependent increase in the zone of inhibition. Conclusions: ZnONPs accelerate the healing of MRSA-infected wounds, suggesting their potential for the treatment of MRSA infection.
dc.description.sponsorshipSelf-funded.
dc.identifier.uridoi: 10.4103/2221-1691.389574
dc.identifier.urihttps://ir.kcu.ac.ug/handle/20.500.14433/37
dc.language.isoen
dc.publisherAsian Pacific Journal of Tropical Biomedicine
dc.relation.ispartofseriesdoi: 10.4103/2221-1691.389574
dc.titleZinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds in rabbits
dc.typeArticle
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